Senior Portfolio & Delivery Manager

About the position Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Senior Manager Portfolio & Delivery advances PMO maturity while ensuring disciplined execution of business system implementations and sustainment initiatives across the organization. This role is responsible for strengthening portfolio governance, modernizing visibility through advanced dashboarding and AI-enabled risk and capacity forecasting, and establishing structured intake and prioritization processes that enable predictable, scalable delivery. In addition, this position directly manages high-impact or strategically significant projects to ensure successful execution and model delivery excellence within the PMO framework. As the organization evolves beyond initial commercial launch, this position ensures IS operates with data-driven transparency, governance rigor, and execution discipline. Key responsibilities include: Portfolio Strategy & Governance Advance and formalize the PMO framework to support commercial launch and post-launch scale. Lead and continuously improve the intake process (business case quality, scoring, prioritization, gating). Lead development and continuous improvement of portfolio governance standards, controls, and reporting structures. Operationalize a structured intake process aligned to strategic priorities and resource capacity. Design and implement a transparent prioritization framework to guide investment decisions. Strengthen and advance the Technology Review Committee (TRC) through structured scoring, impact analysis, and trade-off visibility. Shift governance from reactive coordination to proactive decision enablement. Portfolio Visibility & Predictive Insights Modernize Project Portfolio Dashboards to provide executive-level visibility into delivery health. Incorporate AI-enabled risk prediction, capacity modeling, and planning analytics. Develop forward-looking forecasting models to support budget and resource planning. Provide leadership with actionable insights on portfolio risk, constraints, and trade-offs. Project Management & Delivery Leadership Directly manage complex, high-visibility, or cross-functional business system implementations. Lead projects from initiation through planning, execution, go-live, and stabilization. Develop project plans, resource strategies, and risk mitigation approaches. Monitor scope, budget, timelines, and dependencies in alignment with PMO standards. Facilitate executive-level status reporting and stakeholder communication. Intervene proactively to stabilize projects at risk. Delivery Oversight & Execution Discipline Oversee active business system implementations and sustainment initiatives across the portfolio. Ensure consistent application of PMO standards, tools, and reporting across projects. Monitor cross-functional dependencies, capacity utilization, and execution risks. Partner with functional IS leaders to align delivery plans with available resources. Drive continuous improvement in delivery predictability and operational performance. Serve as a power user for PPM tools (e.g. Smartsheet). Automate reporting where feasible; document processes and run training to uplift adoption. Strategic Impact Predictable, scalable delivery through a modern PMO operating model. Improved portfolio clarity and executive decision-making. Stronger alignment between strategic priorities and resource allocation. Reduced delivery volatility and reactive firefighting. Increased leadership confidence in IS planning and execution.

Responsibilities

• Advance and formalize the PMO framework to support commercial launch and post-launch scale.
• Lead and continuously improve the intake process (business case quality, scoring, prioritization, gating).
• Lead development and continuous improvement of portfolio governance standards, controls, and reporting structures.
• Operationalize a structured intake process aligned to strategic priorities and resource capacity.
• Design and implement a transparent prioritization framework to guide investment decisions.
• Strengthen and advance the Technology Review Committee (TRC) through structured scoring, impact analysis, and trade-off visibility.
• Shift governance from reactive coordination to proactive decision enablement.
• Modernize Project Portfolio Dashboards to provide executive-level visibility into delivery health.
• Incorporate AI-enabled risk prediction, capacity modeling, and planning analytics.
• Develop forward-looking forecasting models to support budget and resource planning.
• Provide leadership with actionable insights on portfolio risk, constraints, and trade-offs.
• Directly manage complex, high-visibility, or cross-functional business system implementations.
• Lead projects from initiation through planning, execution, go-live, and stabilization.
• Develop project plans, resource strategies, and risk mitigation approaches.
• Monitor scope, budget, timelines, and dependencies in alignment with PMO standards.
• Facilitate executive-level status reporting and stakeholder communication.
• Intervene proactively to stabilize projects at risk.
• Oversee active business system implementations and sustainment initiatives across the portfolio.
• Ensure consistent application of PMO standards, tools, and reporting across projects.
• Monitor cross-functional dependencies, capacity utilization, and execution risks.
• Partner with functional IS leaders to align delivery plans with available resources.
• Drive continuous improvement in delivery predictability and operational performance.
• Serve as a power user for PPM tools (e.g. Smartsheet). Automate reporting where feasible; document processes and run training to uplift adoption.

Requirements

• Bachelor’s degree in Business, Information Systems, Science, Engineering, or related field
• 7+ years of progressive experience in portfolio management, PMO leadership, and direct project management.
• Demonstrated success leading complex, cross-functional system implementations.
• Experience advancing PMO maturity in a scaling organization.
• Proven ability to design governance frameworks and prioritization models.
• Strong experience with portfolio reporting tools and dashboard development.
• Exceptional executive communication and stakeholder management skills.

Nice-to-haves

• Experience in biotechnology, life sciences, or regulated environments.
• Familiarity with AI-enabled analytics or predictive portfolio tools.
• PMP, or equivalent certification.
• Lean 6-sigma certification.
• Experience supporting or leading structured governance forums such as a Technology Review Committee.

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