Scientist - Protein Biochemist
About the position Join Amgen's Mission of Serving Patients. At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Responsibilities
- Be actively involved in the design and execution of molecular cloning and protein expression strategies with the Amgen Discovery Protein Science team or CROs.
- Design and execute purification strategies to support the structure determination of drug targets.
- Work closely with structural biologists to generate high-quality protein samples for structural biology techniques, particularly X-ray crystallography and cryo-EM.
- Develop and optimize purification protocols and reagents, ensuring high protein purity, homogeneity, and stability for structural studies.
- Use biochemical and biophysical techniques (e.g., SDS-PAGE, Western blot, spectrophotometry, SEC-MALS, SPR, mass spectrometry) to assess protein quality and stability.
- Collaborate with team members to provide mechanistic insights into the mechanism of action (MOA) of proteins involved in the associated proteins.
- Manage multiple projects simultaneously, ensuring they are completed within timelines while meeting high-quality standards.
- Present research findings effectively in both written and oral formats for internal teams and external collaborators.
- Continuously troubleshoot and optimize experimental workflows, applying creative solutions to overcome challenges in protein production and purification.
Requirements
- Doctorate degree in Biochemistry, Molecular Biology, Structural Biology, or a related field.
- Or Master's degree and 2 years of Biochemistry, Molecular Biology, Structural Biology, or a related field experience.
- Or Bachelor's degree and 4 years of Biochemistry, Molecular Biology, Structural Biology, or a related field experience.
Nice-to-haves
- Experience with microbial systems (e.g., E. coli or yeast) or cell culture (mammalian or insect cells) for protein expression.
- Hands-on experience with biochemical analytical techniques such as spectrophotometry, SDS-PAGE, Western blot, SEC-MALS, SPR, and basic mass spectrometry.
- Familiarity with chromatography systems (e.g., Cytiva AKTA, Agilent HPLC) and related software.
- Expertise in protein purification methods, including affinity, ion exchange, hydrophobic interaction (HIC), and size-exclusion chromatography (SEC).
- Experience with biophysical characterization of protein complexes, including techniques like dynamic light scattering (DLS) and analytical ultracentrifugation (AUC).
- Strong knowledge of protein stability, folding, and quality control for structural studies.
- Excellent presentation skills (written and oral) to effectively communicate research results to both scientific and cross-functional teams.
- Ability to work independently, manage multiple projects, and meet deadlines in a collaborative environment.
- Demonstrated ability to prioritize tasks and manage multiple projects efficiently.
Benefits
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions.
- Group medical, dental and vision coverage.
- Life and disability insurance, and flexible spending accounts.
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
- Stock-based long-term incentives.
- Award-winning time-off plans.
- Flexible work models, including remote and hybrid work arrangements, where possible.
Apply tot his job Apply To this Job